Painter, inspired by Piero della Francesca, he worked in Verrocchio's shop alongside Leonardo. Raphael's father, Giovanni Santi, described them in his poem, written in honour of Federico da Montefeltro around 1485, as «two youths equal in estate and in love».
In 1493 he married Chiara, the daughter of Luca Fancelli da Settignano.
Numerous works of his remain in Florence, among them the Last Supper in the Monastery of Sant’Onofrio, or of Fuligno, rediscovered in the 19th century and initially attributed to Raphael, the fresco of the Crucifixion in Santa Maria Maddalena de’ Pazzi, as well as paintings now in the Palatine Gallery of Palazzo Pitti and in the Uffizi.
It has been suggested that Leonardo may have participated, in the landscape at least, in Perugino's Virgin with two Angels now at the National Gallery in London.