In his youth he was a pupil of Leonardo. He came from Pontorme, a village near the Arno river not far from Empoli and only 10 kilometers from Vinci, represented by Leonardo on his maps. At Pontorme are found today the Saints painted by him in the Church of San Michele, while the house where he was born has been restored and is open to the public.
Among his many works visible in Florence are the Deposition in the Church of Santa Felicita, the frescoes in the Santissima Annunziata and the Certosa del Galluzzo, the Pucci Altarpiece in San Michele Visdomini, the frescoes of the Tabernacle of Boldrone in the Academy of the Art of Drawing, the panel paintings in the Palatine Gallery and the Uffizi. Among his works found outside of Florence, the most famous are the fresco of Vertumnus and Pomona in the Medicean Villa of Poggio a Caiano, the Visitation in the Church of San Michele at Carmignano, the St. Quentin in the Sansepolcro Museum, and the Portrait of a Youth in the Pinacoteca of Palazzo Mansi at Lucca.