Painter, «goldsmith outstanding in his time», as wrote Vasari, he was above all a pupil of Verrocchio (who named him his heir) and a disciple of Leonardo, with whom he had many points in common as regards pictorial style. This is shown by the fact that the Ginevra Benci and the Lady with an Ermine, masterpieces of Leonardian portrait painting, were once attributed to Lorenzo.
In the Uffizi are some of his youthful masterpieces such as the Annunciation and the Venus. At San Domenico di Fiesole can be seen the Baptism of Christ, inspired by that of Verrocchio and Leonardo now in the Uffizi. In the Cathedral of Pistoia is the great altarpiece of the Piazza Madonna, attributed to him, although commissioned of Verrocchio. In this work, some have hypothesised the participation of Leonardo.